TMS治療のうつ病以外の疾患への有効性と安全性についての論文がいくつかでてきています。

今回はADHDに対する有効性と安全性についての論文の紹介、第二弾です。


Positive effects of repetitive transcranial magnetic stimulation on attention in ADHD Subjects: a randomized controlled pilot study.


Bloch, Y., Harel, H.V., Aviram, S., Govezensky, J., Ratzoni, G. &Levkovitz, Y. (2010).
World Journal of Biological Psychiatry , 11 , 755 – 758.


Abstract

OBJECTIVES:

Repetitive transcranial stimulation (rTMS) affects dopaminergic secretion in the prefrontal cortex. Attention deficit hyperactivity disorder (ADHD) had been suggested to involve dopaminergic prefrontal abnormalities.
METHODS:

In this crossover double-blind randomized, sham-controlled pilot study, patients diagnosed as having adult ADHD received either a single session of high-frequency rTMS directed to the right prefrontal cortex (real rTMS) or a single session of sham rTMS.
RESULTS:

A total of 13 patients (seven males, six females) who fulfilled the criteria for adult ADHD, according to DSM-IV criteria gave informed consent and were enrolled. There was a specific beneficial effect on attention 10 minutes after a real rTMS course. The post-real rTMS attention score improved significantly (M=3.56, SD=0.39) compared to the pre-real rTMS attention score (M=3.31, SD=0.5) [t(12)=2.235, P < 0.05]. TMS had no effect on measures of mood and anxiety. The sham rTMS had no effect whatsoever.
CONCLUSIONS:

Our findings should encourage future research on the possibility of amelioration of attention difficulties in patients suffering from ADHD by using high frequency rTMS directed to the right dorsolateral prefrontal cortex. (NIH registry NCT00825708).



この試験でも成人ADHDに対して有効性を認めている。
もちろん効果がでたが、sham群との優位差がでなかったという報告もでている。
TMSの方法も気分障害とは異なるやり方をしており、最適な方法の検討が必要だろう。


記事作成：加藤　晃司（医療法人永朋会）